There’s an expression in medicine, “When you hear hoof beats don’t look for zebras. Look for horses.” What that expression means is that the most common or logical cause for a problem is usually the right answer (the “horses”) while the rare and unusual diagnosis is most likely not the answer (the “zebra”).
Buddy, a 3 year old male Jack Russell Terrier, came in with a history of difficulty swallowing and regurgitating for about a week. A thorough history was unremarkable as were laboratory tests. Radiographs (X-rays) were suspicious for a possible foreign body in the stomach. Endoscopy (a flexible telescope passed into her esophagus and stomach) showed an inflamed esophagus (esophagitis) but no foreign body as did exploratory surgery. Biopsies of multiple organs were normal. After recovery, Buddy was treated for esophagitis, but only slowly and partially responded. He was sent home on continued medication and a prescription diet for the esophagitis while we waited to see if he would continue to progress. In the interim, I consulted a close friend and colleague, Dr. Stan Marks, a world renowned gastroenterologist. After reviewing Buddy’s case with him, we decided to re-evaluate him the following day to check for a particular clinical sign: enlarged salivary glands. Sure enough, the following day we found that his previously normal salivary glands were grossly enlarged but showed no signs of cancer or inflammation. This unusual finding coupled with the clinical signs and surgical findings, revealed a most rare and unusual condition known as Phenobarbital Responsive Sialadenosis. This syndrome is in essence a form of a seizure disorder or limbic seizure. Sure enough, after a few days of continued treatment, Buddy’s salivary glands got smaller, his swallowing returned to normal, and he became a very happy and loving little dog with a great appetite. In fact, instead of trying to “eat” me, he now licks my hand. We all feel gratified by solving a challenging medical puzzle and seeing it as a positive outcome with a very happy pet and pet parent. That’s why I love what I do. And yes, every so often we do see the odd zebra!
